TESTOSTERONE ∙ 3 minute read

Treatment for low testosterone: Testosterone gel & Clomifene 

By Joe Young | Medically reviewed by Dr Luke Pratsides

Low testosterone can leave you feeling like a stranger in your own skin. After blood tests confirm testosterone deficiency, a clinician will determine the best treatment, such as lifestyle intervention, testosterone gel or Clomifene tablets.

But first thing’s first… 

Why should I treat low testosterone?

Testosterone levels tend to decline naturally with age. For many men, this decline is gradual and doesn't cause significant issues. However, some men experience a more pronounced drop in testosterone levels, which can lead to a condition known as low testosterone or hypogonadism.

Low testosterone can bring a long list of unwanted symptoms. Fatigue that clings to you like a shadow, lost libido, muscle mass depleting, a rise in body fat, and mood swings. 

What treatments are available and how do they differ?

Testosterone gel and Clomifene tablets are two of several treatments which are prescribed for the enhancement of low testosterone. Let’s see the key differences:

How does testosterone gel work?

The gel is a straightforward solution - you apply it to your arm to restore your testosterone levels. 

Here’s a breakdown of how it works:: 

Direct hormone replacement: The gel contains synthetic testosterone that's virtually identical to what your body produces naturally. Applying the gel fills the gaps. 

Steady absorption: It’s designed to ensure a consistent release into your bloodstream. There’s no rollercoaster of highs and lows.

Reach optimal levels: The goal is simple - bring your testosterone levels back to the normal or optimal range. This addresses the symptoms, helping you regain your energy, libido, mental sharpness, and physical prowess.

Testosterone gel is proven to be safe and effective for treating the symptoms of low testosterone. 

However, it can take anywhere from 3 to 6 months before you start feeling the transformative effects. Don’t stop or rush the treatment - follow clinical advice at all times. Testosterone gel should be considered a long term treatment and stopping the treatment could mean a return of your symptoms or even their exacerbation.

What are the side effects?

There’s potential for some side effects, such as skin reactions at the application site, increased red blood cell count, prostate growth, and disruption in sleep patterns.

There's a risk of blood clots and the progression of pre-existing prostate cancer. But knowledge is power. Regular blood tests and check-ins with a clinician can mitigate these risks.

You should be aware that testosterone gel can also reduce fertility, so if you're considering starting a family, this treatment might not be suitable for you.

Before you take the plunge, make sure to read the full patient information leaflet. If you're still in the dark, don't hesitate to reach out to our clinical team. 

How do I apply testosterone gel?

Applying the gel isn’t rocket science, but precision is key:

  1. Nail the timing: Use the gel consistently each morning, focusing on dry, smooth skin on your upper arm or shoulder.
  2. Smooth and even: Effortlessly spread the gel in a thin layer. There’s no need to rub too hard. 
  3. Prioritise cleanliness: After application, rinse your hands to avoid unintended transfer.
  4. Let it dry: Allow 3-5 minutes before getting dressed, and ensure the applied region is covered, minimising contact risk for others.
  5. Stay dry: Post application, avoid water activities such as swimming or showering for a minimum of two hours to ensure the gel remains intact.

Testosterone gel can restore hormonal balance.

Next, let's see how Clomifene achieves the same result.

What is Clomifene and how does it work? 

Clomifene is another contender in the battle against low testosterone. But what exactly is it, and how does it measure up?

Clomifene, also known as clomid, clomiphene citrate, or simply clomiphene, is a prescription medication belonging to the selective estrogen receptor modulator (SERM) class. Initially developed to treat infertility in women, it's also effective at battling the symptoms of low testosterone. 

It causes increased secretion of hormones from the pituitary gland in the brain that drive the testicles to produce more testosterone. In simple terms, it jumpstarts your natural production of testosterone.

How do I take Clomifene and what can I expect?

Clomifene is simple to take. Kickstart your morning with a dose every other day - ensure a consistent routine to maximise effectiveness. Pair with a full glass of water and if you miss a dose, simply resume with the same dose on the next day. 

What are the side effects of Clomifene?

Clomifene is generally well-tolerated, and severe side effects are rare. You might encounter mood changes, blurry vision, or breast tissue soreness. Talking with a clinician will help you choose the best course of action for treating low testosterone. 

The numan take

Testosterone gel and Clomifene are science-backed treatments for testosterone deficiency. Both are proven to be effective for treating symptoms. But it all starts with a blood test. Get tested so you can be you again.